August 31st, 2020
CAD4TB is a software product that takes a single PA chest radiograph as input, in the form of a DICOM image, and produces several outputs. Output includes a quality assessment of the input image, a heat map indicating possible areas of abnormalities, and an output score between 0 and 100 related to the likelihood the X-ray demonstrates abnormalities associated with tuberculosis (TB).
CAD4TB is mainly used as a triage/prioritization tool. Because of its ability to work offline and the main output is a score the product doesn't need skilled health care workers to determine which test needs to be done after the triage/screening according to the software. Based on the set threshold local staff can ask the screened person to submit sputum and run a GeneXpert test. After the triage, abnormal images from patients who were GeneXpert-negative can still be read by a skilled radiologist to determine what to do next (for a clinical diagnosis of TB and/or other diseases).
CE 0344 marked
On the market. TRL 9
Online & offline
Intended Age Group
4+ years (regulatory approval)
Primary health centers, government/public sector, e.g. national TB program, private sector
»» Can be used to read images from any kind of chest X-ray machine
»» Chest X-ray image format: DICOM
»» Chest X-ray type: posterior-anterior chest X-ray
»» Other requirements: product requires upload of an original image in the standard DICOM-format which contains appropriate DICOM metadata information in specific DICOM tags
JPG/PNG image format available upon request.
The CAD4TB results consist of:
»» Heat map
»» Probability score for TB
The output format is configurable making it fully compatible with existing infrastructure, such as PACS systems.
Amazon Web Service (AWS) is used. In-country or on-premise servers are available upon request.
For version 6 it is possible to send the heatmap and abnormality score in a DICOM format to a picture archiving and communication system (PACS).
CAD4TB 6 runs on Linux. Currently, Ubuntu LTS 18.04 is preferred.
Less than 20 seconds
CAD4TB comes as a complete product and is installed on a mini computer called the CAD4TBbox.