CAD4TB is CE certified since 2015 by the stringent Dutch regulatory body and new releases come out on a yearly basis. To date, more than 8 million people have been screened with the software across 40 countries.

CAD4TB is a state-of-the-art artificial intelligence (AI) software product that takes a frontal chest radiograph as input and produces several outputs which include an automated quality assessment of the chest image, a heat map indicating possible areas of abnormalities, and a score between 0 and 100 related to the likelihood that the X-ray image demonstrates abnormalities associated with tuberculosis (TB). It can work both online with CAD4TBCloud and offline with the CAD4TBbox. The offline CAD4TB solution is highly relevant for settings with high daily throughput, limited or no stable internet connectivity or for programmes coping with restrained budgets for data exchange over the mobile phone network.

CAD4TB is mainly used as a rapid and accurate triaging tool for TB disease and does not require skilled human readers to determine if the subject is a presumptive TB case requiring further confirmative testing. Based on the set threshold of the CAD4TB tool, local staff can ask the presumptive TB patients to submit sputum and immediately perform a GeneXpert MTB/RIF test. Abnormal chest images from patients who were Xpert MTB/RIF-negative can be read by a skilled human reader to determine what steps to take next (for a clinical diagnosis of TB and/or other lung diseases).

The latest version, CAD4TB 7, has been commercially available since April 2021 with enhanced specificity, among other features, compared with previous versions to further increase savings on Xpert MTB/RIF cartridges. The latest CAD4TB platform also assists TB programmes with overall improved AI performance, an integrated TB screening portal, and advanced management monitoring tools. The new features include digital modules for registration, symptom screening with easy to modify questionnaires, CAD4TB 7 score, patient reporting, and the possibility to seamlessly integrate data from GeneXpert systems. Furthermore, an ‘insights’ module shows statistical representations of the data, including distribution of CAD4TB results based on demographics, such as gender and age.

Additionally, CAD4TB can be complemented with the CAD4COVID-XRay software (CE certified) to support triaging COVID-19 and to enable bi-directional screening for TB and COVID-19.